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文献速递510糖尿病性视网膜病变的预
糖尿病是一组由多病因引起的以慢性高血糖为特征的终身性代谢性疾病。长期的血糖升高容易引起多种并发症，且并发症一旦产生，药物治疗很难逆转，所以及早预防糖尿病的并发症有十分重要的意义。糖尿病性视网膜病变是糖尿病的严重并发症之一，视网膜血管细胞逐渐受损，视网膜水肿，可导致视力障碍甚至失明，但对介导其病变发生发展的途径知之甚少。本研究发现源自19，20-DHDP（19，20-二羟基十五碳五烯酸）的一种生物活性脂质与该病的发病机制相关，为糖尿病性视网膜病变的预防提供新的方向。
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Inhibitionofsolubleepoxidehydrolasepreventsdiabeticretinopathy
Abstract：Diabeticretinopathyisanimportantcauseofblindnessinadults,andischaracterizedbyprogressivelossofvascularcellsandslowdissolutionofinter-vascularjunctions,whichresultinvascularleakageandretinaloedema.Laterstagesofthediseasearecharacterizedbyinflammatorycellinfiltration,tissuedestructionandneovascularization.Hereweidentifysolubleepoxidehydrolase(sEH)asakeyenzymethatinitiatespericytelossandbreakdownofendothelialbarrierfunctionbygeneratingthediol19,20-dihydroxydocosapentaenoicacid,derivedfromdocosahexaenoicacid.TheexpressionofsEHandtheaccumulationof19,20-dihydroxydocosapentaenoicacidwereincreasedindiabeticmouseretinasandintheretinasandvitreoushumourofpatientswithdiabetes.Mechanistically,thedioltargetedthecellmembranetoalterthelocalizationofcholesterol-bindingproteins,andpreventedtheassociationofpresenilin1withN-cadherinandVE-cadherin,thereby白殿疯初期图片SEM主管
